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October 2022

OCTOBER 2022

INTEGRATING CLINICOPATHOLOGIC FEATURES WITH THE 31-GEP OPTIMIZES PATIENT RISK-STRATIFICATION COMPARED TO CLINICOPATHOLOGIC FEATURES ALONE

A recent publication in the Journal of the American Academy of Dermatology (JAAD) highlights the development and validation of an AI algorithm integrating clinicopathological features with a 31-gene expression profile. Titled "Optimizing treatment approaches for patients with cutaneous melanoma by integrating clinical and pathologic features with the 31-gene expression profile test" this study aimed to validate this approach to then provide optimized, personalized risk of recurrence (i31-ROR).

Colorful DNA molecule. Concept image of a structure of the genetic code. 3D illustration of genetic code and science.
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RESEARCH & DEVELOPMENT

DecisionDx-SCC Clinical Impact Study on Utility Presented at the 2022 American Society for Dermatologic Surgery (ASDS)

"How Mohs surgeons utilize prognostic testing for high-risk cutaneous squamous cell carcinoma (SCC): a clinical impact study," was presented by study investigator Sarah T. Arron, M.D., Ph.D., board-certified dermatologist and Mohs surgeon, via a pre-recorded oral presentation.

 

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RESEARCH & DEVELOPMENT

Clinical Use Scenarios for Diagnostic GEP Tests Presented at Maui Derm NP+PA Fall 2022 Conference

The poster, titled "Clinical Utility and a Guide for Using Gene Expression Profile Ancillary Diagnostic Testing for Cutaneous Melanocytic Neoplasms" provides a proposed post-biopsy clinical workflow for the use of Castle's diagnostic GEP tests to achieve more personalized management and treatment plans compared to diagnoses based on histopathology alone.

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CASE STUDY OF THE MONTH

Diagnostic Differentiation Between Evolving Melanoma In Situ or Unusual Clark Nevus with the 35-Gene Expression Profile Test

A case of a 80-year-old male with a difficult-to-diagnose lesion presented by Harold Rabinovitz, M.D. at the 2022 College of American Pathology (CAP) Conference.

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