DecisionDx®-SCC Scientific References

Ibrahim S, Kasprzak J, Hall M et al. Enhanced metastatic risk assessment in cutaneous squamous cell carcinoma with the 40-gene expression profile test. Future Oncology 2021. doi: https://www.futuremedicine.com/doi/10.2217/fon-2021-1277


Wysong, A, Newman J, Covington K et al. Validation of a 40-gene expression profile test to predict metastatic risk in localized high-risk cutaneous squamous cell carcinoma. JAAD 2021; 361-368. doi: https://www.jaad.org/article/S0190-9622(20)30704-0/fulltext


Arron S, Wysong A, Hall M, et al. Gene expression profiling for metastatic risk in head and neck cutaneous squamous cell carcinoma. Laryng Investig Oto 2022; 1-10. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8823155/


Borman S, Wilkinson J, Meldi-Sholl L et al. Analytical validity of DecisionDx-SCC, a gene expression profile test to identify risk of metastasis in cutaneous squamous cell carcinoma (SCC) patients. Diagnostic Pathology 2022. doi: https://diagnosticpathology.biomedcentral.com/articles/10.1186/s13000-022-01211-w

Farberg A, Fitzgerald A, Ibrahim S et al. Current Methods and Caveats to Risk Factor Assessment in Cutaneous Squamous Cell Carcinoma (cSCC): A Narrative Review. Dermatol Ther 2022. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850485/


Au J, Hooper P, Somani AK et al. Clinical Utility of the 40-Gene Expression Profile (40-GEP) Test for Improved Patient Management Decisions and Disease-Related Outcomes when Combined with Current Clinicopathological Risk Factors for Cutaneous Squamous Cell Carcinoma (cSCC): Case Series. Dermatol Ther 2021. doi: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8850491/


Arron S, Blalock T, Guenther M, et al. Clinical considerations for integrating gene expression profiling into cutaneous squamous cell carcinoma management. JDD 2021; s5-s10. doi: https://jddonline.com/articles/clinical-considerations-for-integrating-gene-expression-profiling-into-cutaneous-squamous-cell-carci-S1545961621S005sX/


Farberg AS, Hall MA, Douglas L, et al. Integrating gene expression profiling into NCCN high-risk cutaneous squamous cell carcinoma management recommendations: Impact on patient management. Curr Med Res Opin 2020. doi:10.1080/03007995.2020.1763284.


Litchman GH, Fitzgerald AL, Kurley SJ, et al. Impact of a prognostic 40-gene expression profiling test on clinical management decisions for high-risk cutaneous squamous cell carcinoma. Curr Med Res Opin 2020. 10.1080/03007995.2020.1763283.


Teplitz R, Prado G, Litchman GB, Rigel DS. Impact of gene expression profile testing on the management of squamous cell carcinoma by dermatologistsJ Drugs Dermatol 2019;18:980-4.


Hooper P, Farberg A, Fitzgerald A, et al. Real-World Evidence Shows Clinicians Appropriately Use the Prognostic 40-Gene Expression Profile (40-GEP) Test for High-Risk Cutaneous Squamous Cell Carcinoma (cSCC) Patients. Cancer Investigation  2022. https://doi.org/10.1080/07357907.2022.2116454.


Saleeby E, Bielinski K, Fitzgerald A, et al. A Prospective, Multi-Center Clinical Utility Study Demonstrates that the 40-Gene Expression Profile (40-GEP) Test Impacts Clinical Management for Medicare-Eligible Patients with High-Risk Cutaneous Squamous Cell Carcinoma (cSCC). Skin 2022. https://jofskin.org/index.php/skin/article/view/1788.

SEER data release 2019.


Mansouri B, Housewright CD. The treatment of actinic keratoses— the rule rather than the exception. JAMA Dermatol 2017;153:1200.


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A Review of the DecisionDx-SCC Clinical Validation Study in Future Oncology

by Dr. Sherrif F. Ibrahim

Enhanced Metastatic Risk Assessment in Cutaneous Squamous Cell Carcinoma with the 40-Gene Expression Profile Test: An Interview with the Lead Author of DecisionDx-SCC’s Validation Study.

Speaker: Sherrif F. Ibrahim, MD, PhD., Assistant Professor, Department of Dermatology, University of Rochester Medical Center

Video Webinar

An Introduction to DecisionDx–SCC by Dr. Jason Newman, UPenn

AHNS DecisionDx–SCC Webinar: Identifying the Risk of Metastasis in cSCC and cSCC-HN Patients

Speaker: Dr. Jason Newman, Professor of Otorhinolaryngology - Head and Neck Surgery, University of Pennsylvania

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