
BWH Tumor Staging System
T1 (0 factors)
T2a (1 factor)
T2b (2-3 factors)
T3 (≥4 factors or bone invasion)
Factors include:
- Tumor diameter ≥2 cm
- Poorly differentiated tumor histology
- Perineural invasion ≥0.1 mm
- Tumor invasion beyond fat
Presence of Specific Risk Factors
Factors include:
- Tumor diameter ≥2 cm
- Specific tumor locations (for example, ear, lip, cheek, or temple)
- Immunosuppression
- Tumor invasion beyond fat
- Poorly differentiated histology
- Perineural invasion ≥0.1 mm

NCCN High-Risk
One or more of a large number of possible factors (broadest high-risk characterization)
Similar to Mohs Appropriate Use Criteria
SCC Disease Related Mortality Is on the Rise
7,200
Annual patient deaths from
Annual patient deaths from
Melanoma
15,000
Annual patient deaths from
Annual patient deaths from
SCC
Established management approaches (for primary treatment and follow up/surveillance) provide potential for reduced or earlier detection of metastasis as well as improved survival.